This site is intended for patients who have been prescribed FRAGMIN.
Please check back often as new resources will be added.
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For important safety information click here
About Blood Clots
About Fragmin
Using Fragmin
Resources
Patient Resources
FRAGMIN is a low–molecular-weight heparin that is used to prevent deep vein thrombosis (DVT) in patients who:
Are immobile and hospitalized due to severe illness
Have had hip-replacement surgery
Have had abdominal surgery and are at risk for DVT
 
IMPORTANT SAFETY INFORMATION
  Tell your doctor you are using FRAGMIN® before having certain spinal procedures (spinal puncture or spinal/epidural anesthesia). Use of this medication before these procedures may put you at risk of blood clots in or around the spine. This risk is increased by drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors such as aspirin, and other drugs that prevent clots, when used together with FRAGMIN®. These blood clots around the spine may cause paralysis that may be permanent. Discuss the risks and benefits of treatment with your doctor.

Do not use FRAGMIN® and tell your doctor if you have active major bleeding (bleeding into major organs), an increased risk of bleeding, drop in platelet count known as "thrombocytopenia" or history of "heparin-induced thrombocytopenia."

FRAGMIN® may cause thrombocytopenia (drop in platelet count). Thrombocytopenia needs to be monitored by a doctor.

Do not use FRAGMIN® and tell your doctor if you are allergic or sensitive to the active ingredient called "dalteparin" or "dalteparin sodium," or heparin, or pork products.

In certain situations, FRAGMIN® should not be used with a procedure numbing part of your body (known as regional anesthesia). Tell your doctor you are using FRAGMIN® if you are about to have regional anesthesia. This situation can put you at risk for bleeding, even when the recommended dose of FRAGMIN® is used.

Tell your doctor immediately if you have any bleeding while using FRAGMIN®. This risk is increased when used with other "blood thinning" medications (eg, aspirin, clopidogrel) or NSAIDs (eg, ibuprofen, ketorolac, naproxen).

Tell your doctor if you have any bleeding problems, liver or kidney disease, or eye problems caused by high blood pressure or diabetes. FRAGMIN® should be used with caution in these situations.

Tell your doctor if you are or may be pregnant, or if you become pregnant while taking FRAGMIN®. FRAGMIN® multiple-dose vials contain a preservative that may harm the fetus.

FRAGMIN® must not be injected into the muscle and cannot be substituted with other types of heparins.

Allergic reactions (ie, itching, rash, fever, injection site reaction, and blistering) have occurred rarely. A few cases of serious allergic reactions have been reported. Symptoms of a serious allergic reaction include:
• hives
• swelling of your face, eyelids, lips, tongue, or throat, and trouble swallowing
• asthma (wheezing) or other breathing problems such as chest tightness or shortness of breath
• shock (loss of blood pressure and consciousness)
Get emergency help immediately if you have any of these symptoms.

The most common side effects of FRAGMIN® are swelling and bruising at the site of injection.
   
 
 
 
This Web site contains information relating to various medical conditions and their treatment. Such information is provided for educational purposes only and is not meant to substitute the advice of a physician or other health care professional.

You should not use this information for diagnosing a health problem or disease. Only your doctor can assess the benefits and risks of therapy to determine whether a medication is right for you. You should discuss any questions about you or your loved one’s personal medical needs with your doctor.

The laws, regulatory requirements and medical practices for pharmaceutical products vary from country to country. The information provided in this Web site is intended for residents of the United States only. The products discussed herein may have different product labeling in different countries.

FRAGMIN is a registered trademark of Pfizer Health AB and is licensed to Eisai Inc.
Brought to you by Eisai. Copyright © 2008 Eisai. All rights reserved. Frweb001
 
A blood clot is a jelly-like mass of blood. Normally, blood clots stop bleeding after an injury. But at times, a blood clot can form unexpectedly.
Your heart pumps blood—sending oxygen throughout your body by a system of arteries. After supplying oxygen to your organs, blood returns to your heart through your veins. Blood clots can form in your veins. Blood clots often form in the deep veins of the leg. This is called a deep vein thrombosis or DVT.
Sometimes a clot breaks off and travels to your lungs; this is called a pulmonary embolism or PE. This is a serious problem—it can even threaten your life.
• A leg cramp that gets worse over days
• Pain or swelling in your leg
• Vein swelling near the skin surface
• Reddish-blue skin color
• Skin that is warm to the touch
• Shortness of breath
• Chest pain
• A general sense of anxiety or nervousness
• Feeling lightheaded or blacking out
• Coughing up blood
When part of the blood clot breaks off, it may travel to the
lungs and become
a PE.
When a blood clot
forms, it blocks
normal blood
flow in the
vein.
Seek immediate medical attention if you have any of these symptoms